Is Ativan harmful on a long term use?

Ativan (lorazepam) belong to a group of drugs called benzodiazepines. Lorazepam works on the unbalanced chemicals in the brain and thus are known to treat anxiety disorders. It induces sleep, reduces agitation, and treats nausea, vomiting, and seizures. The drug is known to interfere with new memory formation and in muscle relaxation and hence brings about calming effect. Make sure you read all the details before buying Ativan online to treat your anxiety effectively. The adverse effects of using Ativan are amnesia, depression (suicide ideation in people with weak minds), insomnia and very fatal when used along with alcohol.

Mechanism:

Lorazepam binds to the GABA-A receptor (pentameric ionotropic receptors) in the CNS through an allosteric site. This binding effects the inhibitory neurotransmitter GABA, which results in the opening of the chloride channel in the receptor and allowing chloride influx to take place, thus causing the neuron hyperpolarization.

Withdrawal Symptoms:

When the drug is abruptly withdrawn after a long term use, similar unpleasant signs of anxiety and physical withdrawal as seen in alcohol and barbiturates were observed. It takes 18-36 hours for the benzodiazepine to be removed from the body. Benzodiazepine treatment should be discontinued slowly and gradually by lowering the dose. Any prolonged usage will lead to more and adverse withdrawal symptoms and short-acting benzodiazepines like lorazepam are seen to cause severe withdrawal symptoms. They are:

  • Anxiety and Insomnia
  • Seizures
  • Psychosis
  • Headaches
  • Restlessness
  • Tension
  • Confusion
  • Sweating
  • Irritability
  • Depression
  • Confusion
  • Dysphoria
  • Dizziness
  • Numbness or tingling feeling in the extremities
  • Derealization
  • Hypersensitivity to light
  • Sound and smell
  • Depersonalization
  • Perceptual distortions
  • Diarrhea
  • Nausea and vomiting
  • Loss of appetite
  • Hallucinations
  • Tremor
  • Stomach cramps
  • Delirium
  • Myalgia
  • Palpitations
  • Tachycardia
  • Agitation
  • Panic attacks
  • Hyperthermia and
  • Short term memory loss.

Long term use results:

Using Ativan for a prolonged time results in many harmful effects as it can be habit-forming if it is taken for longer periods than the prescribed dose or if it is consumed for non-medical reasons. Though legal, Ativan drug is as harmful as illegal drugs like heroin or meth as it slows down the functions of the brain and body being a central nervous system depressant. Ativan abuse can have an impact on the person’s psychological, physical and emotional health. And the most serious effects include:

  1. Cognitive impairment
  2. Explicit and Implicit memory impairment
  3. Coma
  4. Behavioral disinhibition
  5. Respiratory depression
  6. Propylene Glycol poisoning
  7. Addiction to the drug
  8. Benzodiazepine withdrawal syndrome
  9. Tolerance to anticonvulsant effects
  10. Cardiovascular depression
  11. Death
  12. Dysarthria

And the warning signs of overdose can be identified with changes in patients, which are: Mental confusion, paradoxical reactions, Drowsiness, Hypotension, Physical/Psychological dependence, hypnotic state, and hypotonia. When Ativan use becomes an addiction, rehabilitation of detoxification treatment is recommended for the patient’s safety.

Overdose or long term usage treatment:

Patients diagnosed with over dosage of the drug due to long term usage will be subjected to emetics, gastric lavage, and activated charcoal and in serious conditions intravenous flumazenil is given. In addition to this, patients are ideally nursed in a kind of serene and non-frustrating environment as they are liable to have developed paradoxical reactions due to a high dose of benzodiazepines.

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